When you try to launch Back 4 Blood, it should start without crashing and then you can set it to open in full screen mode through graphics settings. Press F3 to search for ' bCASSharpening=True' line in the text.Right-click on the ' GameUserSettings.ini' file.Go to ' C:\Users\\AppData\Local\Back4Blood\Steam\Saved\Config\WindowsNoEditor\' folder on your PC.This is caused by the Sharpening setting in the configuration file, which can be fixed using these steps: Some players report that Back 4 Blood launches in borderless windowed mode and then crashes at startup. It appears that Epic Games app fixes the anti-cheat bug that is persistent during the startup of Back 4 Blood.
This may sound like a weird solution, but it did work for many Steam users.
Reddit user Cyndershade has found a bypass to the Steam version crash, which helped a lot of people in the same situation: Those who own Back 4 Blood via the Windows store seem to have more issues, but Steam players are also getting crashing on startup. Back 4 Blood Crashing on Startup Fixes Steam Version Crashing Fix Crashes may be due to your video drivers or related to the Easy Anti-Cheat system adopted by Turtle Rock Studios.